Shanghai Korain Biotech Co., Ltd
Shanghai Korain Biotech Co Ltd
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Highly specific ING2 Rabbit Monoclonal Antibody
Cat.No. BT-MCA0422 Size: 20ul/50ul/100ul Datasheet Request
Product Information
Clonallity: Monoclonal
Applications: WB, ELISA
Source: mouse
Isotype: IgG
Protein Name: ING2
Immunogen: ING2 fusion protein
Calculated molecular weight: 33 kDa
Synonyms: ING1L, ING1Lp, ING2, Inhibitor of growth protein 2, p32, p33ING2
Species specificity: human, mouse, rat
Recommended Dilution:
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Store at 4°C for a month, for one year store at -20°C. When reconstituted in sterile pH 7.4 0.01 M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-20°C. Avoid repeated freeze/thaw cycles.
Background
ING2, also named as ING1L, belongs to the ING family and contains a PHD-type zinc finger. It is induced by the DNA-damaging agents etoposide and neocarzinostatin. As a candidate tumor suppressor, ING2 seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. It is a component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. Recent finding reported that ING2 regulates muscle differentiation by regulating chormatin remodeling program.